Therefore, the present study focused on the evaluation of in vivo antimalarial activities by the hydroalcoholic extracts of. Invitro antimycobacterial activities of endophytic. Oct 22, 20 assessment of in vivo antimalarial activities of some selected medicinal plants from turkey assessment of in vivo antimalarial activities of some selected medicinal plants from turkey ozbilgin, ahmet. Phytochemical screening and in vivo antimalarial activity of. Ilorin, nigeria correspondence should be addressed to mikhail olugbemiro na u. The aim of this study was to evaluate in vivo antimalarial activity of four plants. Investigation of some medicinal plants traditionally used.
A key challenge in the use of medicinal plants in malaria treatment is the. Antimalarial activity of medicinal plants used in traditional medicine in s. Medicinal plants used in traditional treatment of malaria in. In vivo antimalarial activity of extracts of tanzanian medicinal plants used for the treatment of malaria ramadhani so nondo 1, paul erasto 2, mainen j moshi 1, abdallah zacharia 3, pax j masimba 1, abdul w kidukuli 1 1 department of biological and preclinical studies, institute of traditional medicine, muhimbili university of health and allied sciences, dar es salaam, tanzania 2 national. Phytochemical screening and in vivo antimalarial activity of extracts. Sixtynine extracts from 11 plant species were prepared and screened for in vitro activity against p.
Antimalarial activity of some colombian medicinal plants. In vivo antimalarial effect of three medicinal plants 50% ethanol extracts 10 100 80 60 40 20 0 vitex negundo swertia anguistifolia phyllanthus niruri 30 drug doses mgkg body wt. In vivo antimalarial activity of extracts of tanzanian medicinal plants. Products with antimalarial activity have been isolated from plants used against other parasites5,10 and some antimalarial natural products have shown good activity against a broad spectrum of parasites1. In vitro antimalarial activity of six medicinal plants. To document the key medicinal plants used to treat malaria and examining the socioecological factors that influence their use, abundance and distribution. The use of plant to meet healthcare needs has greatly increased worldwide in the recent times.
The current study was therefore designed to evaluate in vivo antimalarial activity and acute toxicity of selected medicinal plants. The increasing global spread of drug resistance to most of the. Screening for in vitro and in vivo antimalarial activity of extracts of traditionally used plants from this region is a strategy for the discovery of new antimalarial substances 8910. The level of activity was discovered to be dose dependent, with the dose of 500 mg kg1 having the highest activity 75. Plants may provide drugs directly such as quinine from cinchona bark or they may provide template molecules on which to base further new structures by organic synthesisartemisinin from artemisia. Eight species, bathysa cuspidata, cosmos sulphureus, cecropia hololeuca. In vivo antiplasmodial activity 4day suppressive tests was. Cryopreserved chloroquine sensitive plasmodium berghei anka strain were first revived and stabilized in mouse host according to ravindran et al. Eyya sm, anthony dj, muhammad y, timothy w 2017 preliminary phytochemical analysis and in vivo antimalarial activity of the crude extracts of the leaf of african mistletoe tapinanthus dodoneifolius against plasmodium berghei in mice. Among the natural compounds, the glycoside derivatives and karavilagenin e revealed the highest activity against both strains of p. Some of them have been documented as having scientific and medicinal values. Herein, the in vitro and in vivo antiplasmodial activity and cytotoxicity of medicinal plant extracts were investigated. In vivo antimalarial activity of extracts of tanzanian medicinal plants used for the. Antimalarial and toxicity studies are therefore important to validate anecdotal efficacy and safety reported by communities using these plants.
Research article phytochemical analysis and antimalarial activity aqueous extract of lecaniodiscus cupanioides root mikhailolugbemironafiu,taoheedadedejiabdulsalam,andmusbauadewumiakanji department of biochemistry, university of ilorin, p. Preliminary phytochemical analysis and in vivo antimalarial. Page 9 g and an excellent source of vitamin c ascorbic acid. The current study was therefore designed to evaluate in vivo antimalarial activity and acute toxicity of selected medicinal plants collected from msambweni district, south coast. Phytochemical analysis and antimalarial activity aqueous.
In africa, the use of indigenous plants plays an important role in the traditional methods of malaria. In vivo antimalarial activity was determined by a 4day suppressive antimalarial assay according to waako et al. Applications, trends, and prospects crc press book malaria is a potentially lifethreatening disease that affects millions worldwide, especially in subsaharan africa. Products with antimalarial activity have been isolated from plants used against other parasites 5,10 and some antimalarial natural products have shown good activity against a broad spectrum of parasites 1. In vivo antiplasmodial activity of two sahelian plant. Medicinal plants play a key role in malaria control in africa, especially in remote areas where health facilities are limited. Results we have investigated eleven indian medicinal plants for their antihyperglycemic activity table 1. Oct 22, 20 resistant infections lead to increased necessity of searching novel drugs and drug combinations. Moreover, medicinal plants and herbs constitute most of the plant. Monteiro da silva flora medicinal leader and his coworkers. In vivo, malaria, medicinal plants, plasmodium berghei. This study also assessed the conservation options available for these plants at community level. Dozens of these plants displayed antimalarial activity. Antimalarial activities of some selected traditional herbs.
The search for new plantderived bioactive agents that can be explored for the treatment of drugresistant malaria infection is urgently needed. Antimalarial activity of two ethiopian medicinal plants. May 12, 2010 there is an urgent need to identify new antimalarial drug targets for both prophylaxis and chemotherapy, due to the increasing problem of drug resistance to malaria parasites. The present study investigates the antimalarial activity of medicinal plants.
Arasit 50 100 aemia p 100 80 70 60 50 40 30 20 10 0 azadirachta indica. Forty plant species indicated to treat malaria were described by dr. The strain was plated in duplicate using a synchronized culture at ringstage parasites, with a parasitaemia between 0. In vivo antimalarial activity, toxicity and phytochemical. Tome and principe stp islands in the gulf of guinea, aiming at identifying the most effective plants for further research. In our antimalarial drug discovery program, we have evaluated more than 2,000 plant extracts against d6 and w2 strains of p. Antimalarial activity of selected malaysian medicinal plants. The present study investigates the antimalarial activity of medicinal plants used in traditional medicine in s. In vitro and in vivo antimalarial activity of plants. A rodent malaria parasite, plasmodium berghei, was used to inoculate healthy male swiss albino mice of age 68 weeks and weight 2327 g. Pdf plants used in traditional medicine have been the source of a number of currently used antimalarial medicines and continue to be a. Research article phytochemical analysis and antimalarial. Surveys have been conducted and plants have been selected to assess their antimalarial properties through in vitro and in vivo biological assays.
Thus, we evaluated the antimalarial activity of three medicinal plants used in nigerian folklore for the treatment of malaria infection. Medicinal plants used in traditional treatment of malaria. In vivo antimalarial activity of the crude leaf extract. Antimalarial activity and acute toxicity of four plants. In vivo and in vitro antimalarial activity of vernonia. In vivo antimalarial activity of solvent fractions of the. Pdf in vivo antimalarial activity of extracts of tanzanian medicinal. In vivo antimalarial activity of extracts of tanzanian. Malaria is endemic to the amazon region where plasmodium falciparum and. Phytochemical screening and in vivo antimalarial activity.
Assessment of in vivo antimalarial activities of some. Terrestrial plants have been demonstrated to be sources of antimalarial compounds. The purpose of this paper was to investigate antimalarial properties of some selected medicinal plants that have been traditionally used in turkey for antipyretic and analgesic purposes. Phytochemical screening and in vivo antimalarial activity of extracts from three medicinal plants used in malaria treatment in nigeria. A search of cuban medicinal species with antimalarial activity is.
Assessment of in vivo antimalarial activities of some selected medicinal plants from turkey assessment of in vivo antimalarial activities of some selected medicinal plants from turkey ozbilgin, ahmet. Alsllami3 and ulrike lindequist4 1department of microbiology, shphaco pharmaceutical ind. In order to assess their acclaimed potentials, eleven extracts were prepared from seven selected plants commonly used in western cameroon, and tested both for their antiplasmodial activity and cytotoxicity. Antihyperglycemic activity of compounds isolated from. Tome and prncipe stp islands in the gulf of guinea, aiming at identifying the most effective plants for further research. To identify medicinal plants which would provide potential lead compounds, this study evaluated the extracts of erythrina schliebenii harms fabaceae, holarrhena pubescens buchham apocynaceae, phyllanthus nummulariifolius poir euphorbiaceae, and caesalpinia bonducella l. There is an urgent need to identify new antimalarial drug targets for both prophylaxis and chemotherapy, due to the increasing problem of drug resistance to malaria parasites.
Resistant infections lead to increased necessity of searching novel drugs and drug combinations. Extracts obtained from the leaves of annona muricata, ficus polita, luffa aegyptiaca, momordica charantia and newbouldia laevis and from the twigs and leaves of moringa pterygosperma were screened for antimalarial action against plasmodium falciparum cultured in vitro. In vivo antimalarial activity was assessed using the 4day suppressive antimalarial assay. Pdf phytochemical screening and in vivo antimalarial. Sep 22, 2015 the in vivo antimalarial activity of aqueous extracts of the leaves of m. In vitro and in vivo antimalarial activity of boerhavia. Agbaje and onabanjo 1991 reported that aqueous extract of the plant e. In vitro antiplasmodial activity and cytotoxicity of. The in vivo antimalarial activity of aqueous extracts of the leaves of m. Therefore in order to make health care accessible to 80% of rural people and now, increasingly urban people it is critical to sustain the medicinal plant resource base. In vivo antimalarial effect of three medicinal plants aqueous extracts fig. In the present study, the aim was to discover novel, effective plantbased extracts for the activity against malaria. In vitro antimalarial activity and cytotoxicity of some. Antimalarial activity of medicinal plants used in traditional.
Increasing resistance of plasmodium falciparum to almost all the available antimalarial drugs urges a search for newer antimalarial drugs. Assessment of antimalarial activity against plasmodium. Investigation of some medicinal plants traditionally used for treatment of malaria in kenya as potential sources of antimalarial drugs c. Traditional medicinal plants for the treatment and. Antimalarial and antivectoral activities of traditionally. Screening of naturalsynthetic compounds for antimalarial. Plants used traditionally to treat malaria in brazil.
This study was designed to evaluate the in vivo antimalarial activity and acute toxicity of selected medicinal plants commonly used in msambweni district, south coast of kenya for the treatment of malaria. Using medicinal plants is a good alternative to modern antimalarial drugs, especially for the majority of those populations at. Pdf in vitro antimalarial activity of medicinal plant. Ethanolic extracts of pongamia pinnata fruits, tinospora cordifolia stems, ficus bengalensis aerial.
I traditional medicinal plants for the treatment and prevention of human parasitic diseases merlin l willcox, benjamin gilbert encyclopedia of life support systems eolss many plants with antiparasitic properties, and often these plants contain several compounds which contribute together to this activity. Ten plants found in iran were selected by ethnobotanical survey of medicinal plants. All six extracts were found to inhibit the growth of p. Comparative study of antimalarial effect of sambiloto. The articles selected concern studies on ethnobotany. Therefore, the present study focused on the evaluation of in vivo antimalarial activities by the hydroalcoholic extracts of these two plants against plasmodium berghei in mice. The in vitro antiplasmodial activity and cytotoxicity of extracts from jatropha tanjorensis leaves. The recent emergence and spread of multidrug resistance in parts of southeast asia prompts the urgent need for novel and effective therapy against. Antimalarial and antiplasmodial activity papaya leaves are made into tea as a treatment for malaria. Ex nees is traditionally used for the treatment of malaria and a study conducted previously on the crude leaf extract confirmed that the plant is endowed with antimalarial activity.
Plants which have been used for centuries as alternative sources of medicine particularly in africa need to be explored for anti malaria activity in order to counteract the challenges associated with the disease 12. Traditional medicinal plants for the treatment and prevention. Antimalarial activity and in vivo toxicity of selected. In vivo and in vitro antimalarial activity of vernonia amygdalina. Malaria is endemic to the amazon region where plasmodium falciparum and plasmodium vivax. The antimalarials quinine and artemisinin were isolated from traditionally used plants cinchona spp. The objective of the present study was to investigate phytochemical components, antiplasmodial activity in vivo and evaluate the toxicity of two local medicinal plants, namely, salvadora persica l. Flem caesalpiniacea for in vivo antimalarial activity in mice. In vitro antimalarial activity and cytotoxicity of.
A search of cuban medicinal species with antimalarial activity is being developed in our laboratory. Rukungaa a centre for traditional medicine and drug research, kenya medical research institute, p. Medicinal plants are used to treat diseases also where the biodiversity of plants occur in parallel with endemic transmission of malaria. Hot water extracts from eight medicinal plants representing five families, used for malaria treatment in kenya were screened for their in vivo antimalarial activity in mice against a chloroquine cq resistant plasmodium berghei nk65, either alone or in combination with cq. Antimalarial and antivectoral activities of traditionally used indigenous medicinal plants abstract malaria is the worldwide most important parasitic disease with an incidence of almost 300 millions clinical cases and over one million deaths per year. Antimalarial efficacy and toxicological assessment of extracts of. In vitro antimalarial activity of medicinal plant extracts against plasmodium falciparum article pdf available in parasitology research 1081. All this plants have been used traditionally for various purposes by the old folks. Erythrina schliebenii harms, holarrhena pubescens buchham, phyllanthus nummulariifolius poir, and caesalpinia bonducella l. In vitro and in vivo antimalarial activity of linolenic. This study therefore aimed at investigating the in vivo antiplasmodial activity of 80% methanol extract and solvent fractions of the leaves of croton macrostachyus h. The percentage use of the herb by the giziga is as follows. The archives of flora medicinal, an ancient pharmaceutical laboratory that supported ethnomedical research in brazil for more than 30 years, were searched for plants with antimalarial use. In vivo antimalarial effect of three medicinal plants aqueous extracts ethanol extract 50% of 9 medicinal plants were tested in vitro for their antimalarial activities using cq sensitive isolate.
In this study, phytochemical screening has been done using standard methods and the existence of. In vitro and in vivo antimalarial activity of plants from. This study investigated the antimalarial activity, toxicity and the nature of major chemical classes present in four medicinal plants. Erythrina schliebenii harms, holarrhena pubescens buchham, phyllanthus nummulariifolius poir, and caesalpinia. It is therefore of interest to screen traditional antimalarial medicinal plants for an evaluation if in vitro antiplasmodial, in vivo antimalarial and toxicity tests muthaura, et al. In vitro antiplasmodial activity and cytotoxicity of extracts. Screening of naturalsynthetic compounds for antimalarial activity plants have been used as a traditional medicine for the treatment of malaria. The antiplasmodial activity was assessed using lactate. Pdf phytochemical screening and in vivo antimalarial activity of. Sep 22, 2015 the use of plant to meet healthcare needs has greatly increased worldwide in the recent times. So, we included in our investigation, in addition to antimalarials and antipyretics, plant species used in our country as antiparasitic. The assessment of the in vitro antiplasmodial activity of cassia sieberiana leaves extracts showed a very good activity 100% of plasmodium elimination 4.
222 996 428 121 1234 909 1191 1157 200 1088 603 1101 1536 587 634 288 3 525 224 860 1226 363 1197 636 952 35 59 581 397 1399